BLUE BELL, PA August 23, 2004 -- InKine Pharmaceutical Company,
Inc. (Nasdaq: INKP)
today announced that a manuscript by Jeffrey Medoff, M.D., F.A.C.G., et. al., reporting the results of the Company’s Phase IV study of Visicol®’s use in treating adult patients with chronic constipation has been accepted for publication by the journal Clinical Therapeutics®. Clinical Therapeutics is a peer-reviewed, international, monthly journal that publishes original reports of recent developments in drug therapy as well as in-depth reviews of specific drug therapies or disease states. Publication is expected in the fall of this year.
“We are very pleased Clinical Therapeutics has accepted our paper for publication,” said Martin Rose, M.D., J.D., who is an author of the paper and InKine’s Executive Vice President for Research and Development. “The highly positive results of this study in terms of the efficacy and tolerability of low-dose Visicol® in constipated adults support additional studies to obtain a labeled constipation indication,” added Dr. Rose.
In this open label, multicenter, Phase IV study, patients with functional constipation or constipation-predominant IBS were randomized to receive one of two low-doses of Visicol® tablets each day for 4 weeks. Dose titration within specified limits was allowed after 2 days based on the response to therapy. In addition to the paper in Clinical Therapeutics, the results of the study will be presented at the 69th Annual Scientific Meeting of the American College of Gastroenterology, to be held in Orlando, Florida from October 31 – November 4, 2004.
About InKine Pharmaceutical
InKine Pharmaceutical Company,
is a publicly traded specialty pharmaceutical company focused on developing and commercializing pharmaceutical products for the diagnosis and treatment of gastrointestinal disorders. The Company's development strategy is to acquire late-stage drug candidates with short time lines to commercialization. The Company's franchise product, Visicol® is the only tablet purgative preparation indicated for bowel cleansing prior to colonoscopy. InKine's second product, IB-Stat®, is an oral hyoscyamine spray for the treatment of a variety of indications. The Company is also promoting VSL#3®, a probiotic that is effective in treating certain gastrointestinal disorders. Additionally, the Company is developing INKP-102, an advanced generation purgative, which recently completed Phase II clinical trials for bowel cleansing prior to colonoscopy, Visicol® for use as a laxative in treating patients with constipation and Colirest™, which is in clinical trials for the treatment of Crohn's disease. For further information, please visit InKine on its web site http://www.inkine.com.
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